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Diet seems to be an important driver of disease pathogenesis in eosinophilic gastroenteritis, with elimination and elemental diets showing promise in management, with further robust trials required. Several primary gastrointestinal disorders are associated with an increase in inflammatory cells including eosinophils. A gluten-free diet that excludes the abovementioned triggers is the cornerstone of treatment however, unlike celiac disease, there is uncertainty about the level of adherence or whether the gluten-free diet is a lifelong intervention. The diagnosis can be challenging, given the lack of validated biomarkers. Although gluten is believed to be a potential trigger for symptoms, other components of wheat may also be triggers, including fructans, alpha-amylase trypsin inhibitors, and wheat germ agglutinins.
Self-reported nonceliac gluten/wheat sensitivity is prevalent. There are predominantly 3 small bowel conditions that have potential dietary interventions.
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This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ĭiet plays a key role in the manifestation and severity of gastrointestinal symptoms, with increasing research interest on the role of diet in small bowel disorders. 1Academic Unit of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, England ĢFaculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia ģFaculty of Medicine and Faculty of Health and Behavioral Sciences, The University of Queensland, Brisbane, Australia ĤDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia ĥAGIRA (Australian Gastrointestinal Research Alliance) and the NHMRC Centre of Research Excellence in Digestive Health, Brisbane, Australia ĦAcademic Unit of Gastroenterology, Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.Ĭorrespondence: Anupam Rej, MBChB, BMedSci, MD, MRCP.
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